Nanomedicine

Nanomedicine Lab (NanoMed)

Principal Investigator: Dr. Mohammad Moeini

Location: Department of Biomedical Engineering, 7th floor

 

Nanomedicine Lab was founded in 2019 in the Department of Biomedical Engineering at Amirkabir University of Technology (AUT, known as Tehran Polytechnic). Our research is mainly focused on the application of nanostructures in tissue engineering and regenerative medicine. Two major fields of research in this lab are:

Nano-composite hydrogels for soft tissue engineering

Hydrogels are often considered an optimal choice for engineering of soft tissue (such as brain). Incorporation of nanostructures in the hydrogels can enhance their efficacy in many ways. Nanostructures can optimize the chemical and physical properties of the hydrogel or act as bioactive cues for enhancing cell function. Using nanostructures, it is possible to release bioactive agents in a controlled manner or to produce physical and chemical gradients/patterns to achieve a desired cellular response. If combined with external stimuli, such as laser light or magnetic field, both the release of the bioactive agents and the imposed chemical/physical patterns can be controlled remotely. Similarly, light or magnetic field can be used in combination with nanostructures to externally apply a wide range of physical or chemical stimuli (such as cyclic deformation or pulsed release of agents). One more area of interest is the formulation of in situ-forming injectable hydrogels (carrying cells and drugs) using self-assembling units for the repair of soft tissue.

Smart nanostructures for targeted imaging and therapy

Rationally designed nanostructures can target specific cells or tissue, allowing the study of tissue physiology and pathophysiology. This is critically important for early detection of diseases and/or tissue degeneration. These nanostructures can also be used for targeted drug delivery. Again in combination with an external stimulus like laser light or magnetic field, we can achieve remotely controlled, “on demand” drug release. Furthermore, the imaging and therapeutic agents can be integrated in one nanostructure (theranostics), or they can be made sensitive to different biological parameters (such as pH or temperature). Such smart nanostructures are of immense interest for a wide range of practical applications, including cancer research and treatment.

 

Interested students or collaborators are encouraged to contact Dr. Mohammad Moeini (m.moeini@aut.ac.ir).